Could alkalinization worsen local anesthetic systemic toxicity?

Local anesthetics (LA) are sodium channel antagonists commonly used for pain control by anesthesiologists, emergency physicians, den- tists, and other clinicians [1]. Unintentional intravascular injection or overdose may lead to local anesthetic systemic toxicity (LAST), which is characterized by paresthesias, angor animi, seizures, ventricular dys- rhythmias, and cardiac arrest [2].