Glucocorticoid with cyclophosphamide for oral paraquat poisoning

Conclusion :

Low-certainly evidence suggests that glucocorticoids with  cyclophosphamide in addition to standard care may slightly reduce  mortality in hospitalised people with oral paraquat poisoning. However,  we have limited confidence in this finding because of substantial  heterogeneity and concerns about imprecision. Glucocorticoids with  cyclophosphamide in addition to standard care may have little or no  effect on mortality at three months after hospital discharge. We are  uncertain whether glucocorticoid with cyclophosphamide puts patients at  an increased risk of infection due to the limited evidence available for  this outcome. Future research should be prospectively registered and  CONSORT-compliant. Investigators should attempt to ensure an adequate  sample size, screen participants for inclusion rigorously, and seek  long-term follow-up of participants. Investigators may wish to research  the effects of glucocorticoid in combination with other treatments.