Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis

Déc, 2023

Despite the abundance of epidemiological evidence concerning the association between pesticide exposure and adverse health outcomes including acute childhood leukemia (AL), evidence remains inconclusive, and is inherently limited by heterogeneous exposure assessment and multiple statistical testing. We performed a literature search of peer-reviewed studies, published until January 2021, without language restrictions. Sum- mary odds ratios (OR) and 95% confidence intervals (CI) were derived from stratified random-effects meta- analyses by type of exposure and outcome, exposed populations and window of exposure to address the large heterogeneity of existing literature. Heterogeneity and small-study effects were also assessed. We identified 55 eligible studies (n = 48 case-control and n = 7 cohorts) from over 30 countries assessing >200 different ex- posures of pesticides (n = 160,924 participants).

Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis

Effets retardés d’une exposition intra-utérine. Risques de cancer